Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution

Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA. Using single-molecule FRET, we show that AID bind...

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Publicat a:Nat Commun
Autors principals: Senavirathne, Gayan, Bertram, Jeffrey G., Jaszczur, Malgorzata, Chaurasiya, Kathy R., Pham, Phuong, Mak, Chi H., Goodman, Myron F., Rueda, David
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703863/
https://ncbi.nlm.nih.gov/pubmed/26681117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10209
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