Rapamycin Attenuates Splenomegaly in both Intrahepatic and Prehepatic Portal Hypertensive Rats by Blocking mTOR Signaling Pathway

BACKGROUND: Spleen enlargement is often detected in patients with liver cirrhosis, but the precise pathogenetic mechanisms behind the phenomenon have not been clearly elucidated. We investigated the pathogenetic mechanisms of splenomegaly in both portal hypertensive patients and rats, and tried to i...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Chen, Yunyang, Wang, Weijie, Wang, Huakai, Li, Yongjian, Shi, Minmin, Li, Hongwei, Yan, Jiqi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703391/
https://ncbi.nlm.nih.gov/pubmed/26734934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141159
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items