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Detection of secondary binding sites in proteins using fragment screening

Proteins need to be tightly regulated as they control biological processes in most normal cellular functions. The precise mechanisms of regulation are rarely completely understood but can involve binding of endogenous ligands and/or partner proteins at specific locations on a protein that can modula...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ludlow, R. Frederick, Verdonk, Marcel L., Saini, Harpreet K., Tickle, Ian J., Jhoti, Harren
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703025/
https://ncbi.nlm.nih.gov/pubmed/26655740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518946112
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