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Detection of secondary binding sites in proteins using fragment screening
Proteins need to be tightly regulated as they control biological processes in most normal cellular functions. The precise mechanisms of regulation are rarely completely understood but can involve binding of endogenous ligands and/or partner proteins at specific locations on a protein that can modula...
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Publicado no: | Proc Natl Acad Sci U S A |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4703025/ https://ncbi.nlm.nih.gov/pubmed/26655740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518946112 |
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