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Covalent-fragment screening of BRD4 identifies a ligandable site orthogonal to the acetyl-lysine binding sites
BRD4, a member of the bromodomain and extraterminal domain (BET) family, has emerged as a promising epigenetic target in cancer and inflammatory disorders. All reported BET family ligands bind within the bromodomain acetyl-lysine binding sites and competitively inhibit BET protein interaction with a...
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| Izdano u: | ACS Chem Biol |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7271629/ https://ncbi.nlm.nih.gov/pubmed/32149490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00058 |
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