Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome

Double-stranded RNA (dsRNA) activates the innate immune system of mammalian cells and triggers intracellular RNA decay by the pseudokinase and endoribonuclease RNase L. RNase L protects from pathogens and regulates cell growth and differentiation by destabilizing largely unknown mammalian RNA target...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Rath, Sneha, Donovan, Jesse, Whitney, Gena, Chitrakar, Alisha, Wang, Wei, Korennykh, Alexei
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702973/
https://ncbi.nlm.nih.gov/pubmed/26668391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513034112
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