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Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome
Double-stranded RNA (dsRNA) activates the innate immune system of mammalian cells and triggers intracellular RNA decay by the pseudokinase and endoribonuclease RNase L. RNase L protects from pathogens and regulates cell growth and differentiation by destabilizing largely unknown mammalian RNA target...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4702973/ https://ncbi.nlm.nih.gov/pubmed/26668391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513034112 |
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