Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L

Cells of all mammals recognize double-stranded RNA (dsRNA) as a foreign material. In response, they release interferons (IFNs) and activate a ubiquitously expressed pseudokinase/endoribonuclease RNase L. RNase L executes regulated RNA decay and halts global translation. Here, we developed a biosenso...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chitrakar, Alisha, Rath, Sneha, Donovan, Jesse, Demarest, Kaitlin, Li, Yize, Sridhar, Raghavendra Rao, Weiss, Susan R., Kotenko, Sergei V., Wingreen, Ned S., Korennykh, Alexei
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369740/
https://ncbi.nlm.nih.gov/pubmed/30655338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818363116
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