Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L

Cells of all mammals recognize double-stranded RNA (dsRNA) as a foreign material. In response, they release interferons (IFNs) and activate a ubiquitously expressed pseudokinase/endoribonuclease RNase L. RNase L executes regulated RNA decay and halts global translation. Here, we developed a biosenso...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Chitrakar, Alisha, Rath, Sneha, Donovan, Jesse, Demarest, Kaitlin, Li, Yize, Sridhar, Raghavendra Rao, Weiss, Susan R., Kotenko, Sergei V., Wingreen, Ned S., Korennykh, Alexei
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369740/
https://ncbi.nlm.nih.gov/pubmed/30655338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818363116
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares