Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response

One of the hallmark mechanisms activated by type I interferons (IFNs) in human tissues involves cleavage of intracellular RNA by the kinase homology endoribonuclease RNase L. We report 2.8 and 2.1 angstrom crystal structures of human RNase L in complexes with synthetic and natural ligands and a frag...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Han, Yuchen, Donovan, Jesse, Rath, Sneha, Whitney, Gena, Chitrakar, Alisha, Korennykh, Alexei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731867/
https://ncbi.nlm.nih.gov/pubmed/24578532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1249845
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller