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Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response
One of the hallmark mechanisms activated by type I interferons (IFNs) in human tissues involves cleavage of intracellular RNA by the kinase homology endoribonuclease RNase L. We report 2.8 and 2.1 angstrom crystal structures of human RNase L in complexes with synthetic and natural ligands and a frag...
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| Publicat a: | Science |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4731867/ https://ncbi.nlm.nih.gov/pubmed/24578532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1249845 |
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