Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity

Changes of histone modification status at critical lineage-specifying gene loci in multipotent precursors can influence cell fate commitment. The contribution of these epigenetic mechanisms to natural killer (NK) cell lineage determination from common lymphoid precursors is not understood. Here we i...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Yin, Jie, Leavenworth, Jianmei W., Li, Yang, Luo, Qi, Xie, Huafeng, Liu, Xinhua, Huang, Shan, Yan, Han, Fu, Zheng, Zhang, Liyun Y., Zhang, Litao, Hao, Junwei, Wu, Xudong, Deng, Xianming, Roberts, Charles W. M., Orkin, Stuart H., Cantor, Harvey, Wang, Xi
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2015
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702963/
https://ncbi.nlm.nih.gov/pubmed/26668377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521740112
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