Glucocorticoid Excess Increases Hepatic 11β-HSD-1 Activity in Humans: Implications in Steroid-Induced Diabetes

CONTEXT: Animal studies indicate that glucocorticoids increase hepatic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) expression and activity. OBJECTIVE: Our goal was to determine whether glucocorticoid excess increases cortisol production in the liver via 11β-HSD-1 enzyme pathway in humans. DE...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Dube, Simmi, Slama, Michael Q., Basu, Ananda, Rizza, Robert A., Basu, Rita
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702452/
https://ncbi.nlm.nih.gov/pubmed/26308294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2015-2673
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