Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11β-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells

BACKGROUND: Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes involved in drug metabolism and defence against oxidative stress. The glucocorticoid receptor (GR) is a ligand-induced transcription factor...

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Main Authors: Kratschmar, Denise V., Calabrese, Diego, Walsh, Jo, Lister, Adam, Birk, Julia, Appenzeller-Herzog, Christian, Moulin, Pierre, Goldring, Chris E., Odermatt, Alex
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350474/
https://ncbi.nlm.nih.gov/pubmed/22606287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036774
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