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Identification and classification of small molecule kinases: insights into substrate recognition and specificity

BACKGROUND: Many prokaryotic kinases that phosphorylate small molecule substrates, such as antibiotics, lipids and sugars, are evolutionarily related to Eukaryotic Protein Kinases (EPKs). These Eukaryotic-Like Kinases (ELKs) share the same overall structural fold as EPKs, but differ in their modes o...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:BMC Evol Biol
Prif Awduron: Oruganty, Krishnadev, Talevich, Eric E., Neuwald, Andrew F., Kannan, Natarajan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702295/
https://ncbi.nlm.nih.gov/pubmed/26738562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-015-0576-x
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