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Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases
The protein kinase catalytic domain contains several conserved residues of unknown functions. Here, using a combination of computational and experimental approaches, we show that the function of some of these residues is to maintain the backbone geometry of the active site in a strained conformation...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549070/ https://ncbi.nlm.nih.gov/pubmed/23277537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207104110 |
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