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Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Protein tyrosine kinases (PTKs) are a group of closely related enzymes that have evolutionarily diverged from serine/threonine kinases (STKs) to regulate pathways associated with multi-cellularity. Evolutionary divergence of PTKs from STKs has occurred through accumulation of mutations in the active...

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Detalhes bibliográficos
Main Authors: Smita Mohanty, Krishnadev Oruganty, Annie Kwon, Dominic P Byrne, Samantha Ferries, Zheng Ruan, Laura E Hanold, Samiksha Katiyar, Eileen J Kennedy, Patrick A Eyers, Natarajan Kannan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2016-02-01
Colecção:PLoS Genetics
Acesso em linha:http://europepmc.org/articles/PMC4771162?pdf=render
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