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Modeling the evolution space of breakage fusion bridge cycles with a stochastic folding process

Breakage–fusion–bridge cycles in cancer arise when a broken segment of DNA is duplicated and an end from each copy joined together. This structure then ‘unfolds’ into a new piece of palindromic DNA. This is one mechanism responsible for the localised amplicons observed in cancer genome data. Here we...

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Bibliografski detalji
Izdano u:J Math Biol
Glavni autori: Greenman, C. D., Cooke, S. L., Marshall, J., Stratton, M. R., Campbell, P. J.
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702116/
https://ncbi.nlm.nih.gov/pubmed/25833184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00285-015-0875-2
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