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Breakage-fusion-bridge Cycles and Large Insertions Contribute to the Rapid Evolution of Accessory Chromosomes in a Fungal Pathogen

Chromosomal rearrangements are a major driver of eukaryotic genome evolution, affecting speciation, pathogenicity and cancer progression. Changes in chromosome structure are often initiated by mis-repair of double-strand breaks in the DNA. Mis-repair is particularly likely when telomeres are lost or...

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Detalhes bibliográficos
Main Authors: Croll, Daniel, Zala, Marcello, McDonald, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681731/
https://ncbi.nlm.nih.gov/pubmed/23785303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003567
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