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Whole chromosome loss and associated breakage–fusion–bridge cycles transform mouse tetraploid cells
Whole chromosome gains or losses (aneuploidy) are a hallmark of ~70% of human tumors. Modeling the consequences of aneuploidy has relied on perturbing spindle assembly checkpoint (SAC) components, but interpretations of these experiments are clouded by the multiple functions of these proteins. Here,...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5770879/ https://ncbi.nlm.nih.gov/pubmed/29196303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797630 |
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