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STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication

The life cycle of high-risk human papillomaviruses (HPVs) is dependent upon epithelial differentiation. Following infection of basal cells, HPV genomes are stably maintained at low copy numbers, and productive replication or amplification is restricted to highly differentiated suprabasal cells. In h...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Hong, Shiyuan, Cheng, Shouqiang, Iovane, Andre, Laimins, Laimonis A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701836/
https://ncbi.nlm.nih.gov/pubmed/26695634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02006-15
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