An Interaction between Human Papillomavirus 16 E2 and TopBP1 Is Required for Optimum Viral DNA Replication and Episomal Genome Establishment

In human papillomavirus DNA replication, the viral protein E2 forms homodimers and binds to 12-bp palindromic DNA sequences surrounding the origin of DNA replication. Via a protein-protein interaction, it then recruits the viral helicase E1 to an A/T-rich origin of replication, whereupon a dihexamer...

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Detalhes bibliográficos
Main Authors: Donaldson, Mary M., Mackintosh, Lorna J., Bodily, Jason M., Dornan, Edward S., Laimins, Laimonis A., Morgan, Iain M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497701/
https://ncbi.nlm.nih.gov/pubmed/22973044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01002-12
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