An Interaction between Human Papillomavirus 16 E2 and TopBP1 Is Required for Optimum Viral DNA Replication and Episomal Genome Establishment

In human papillomavirus DNA replication, the viral protein E2 forms homodimers and binds to 12-bp palindromic DNA sequences surrounding the origin of DNA replication. Via a protein-protein interaction, it then recruits the viral helicase E1 to an A/T-rich origin of replication, whereupon a dihexamer...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Donaldson, Mary M., Mackintosh, Lorna J., Bodily, Jason M., Dornan, Edward S., Laimins, Laimonis A., Morgan, Iain M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497701/
https://ncbi.nlm.nih.gov/pubmed/22973044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01002-12
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky