An Interaction between Human Papillomavirus 16 E2 and TopBP1 Is Required for Optimum Viral DNA Replication and Episomal Genome Establishment

In human papillomavirus DNA replication, the viral protein E2 forms homodimers and binds to 12-bp palindromic DNA sequences surrounding the origin of DNA replication. Via a protein-protein interaction, it then recruits the viral helicase E1 to an A/T-rich origin of replication, whereupon a dihexamer...

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Autors principals: Donaldson, Mary M., Mackintosh, Lorna J., Bodily, Jason M., Dornan, Edward S., Laimins, Laimonis A., Morgan, Iain M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497701/
https://ncbi.nlm.nih.gov/pubmed/22973044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01002-12
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