Molecular and Mechanical Causes of Microtubule Catastrophe and Aging

Tubulin polymers, microtubules, can switch abruptly from the assembly to shortening. These infrequent transitions, termed “catastrophes”, affect numerous cellular processes but the underlying mechanisms are elusive. We approached this complex stochastic system using advanced coarse-grained molecular...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Zakharov, Pavel, Gudimchuk, Nikita, Voevodin, Vladimir, Tikhonravov, Alexander, Ataullakhanov, Fazoil I., Grishchuk, Ekaterina L.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2015
Fag:
Molecular Machines, Motors, and Nanoscale Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701015/
https://ncbi.nlm.nih.gov/pubmed/26682815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.10.048
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