Molecular and Mechanical Causes of Microtubule Catastrophe and Aging

Tubulin polymers, microtubules, can switch abruptly from the assembly to shortening. These infrequent transitions, termed “catastrophes”, affect numerous cellular processes but the underlying mechanisms are elusive. We approached this complex stochastic system using advanced coarse-grained molecular...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Zakharov, Pavel, Gudimchuk, Nikita, Voevodin, Vladimir, Tikhonravov, Alexander, Ataullakhanov, Fazoil I., Grishchuk, Ekaterina L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Molecular Machines, Motors, and Nanoscale Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701015/
https://ncbi.nlm.nih.gov/pubmed/26682815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.10.048
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