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HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells
BACKGROUND: HIV-1 integration is prone to a high rate of failure, resulting in the accumulation of unintegrated viral genomes (uDNA) in vivo and in vitro. uDNA can be transcriptionally active, and circularized uDNA genomes are biochemically stable in non-proliferating cells. Resting, non-proliferati...
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| 發表在: | Retrovirology |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4700562/ https://ncbi.nlm.nih.gov/pubmed/26728316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0234-9 |
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