HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells

BACKGROUND: HIV-1 integration is prone to a high rate of failure, resulting in the accumulation of unintegrated viral genomes (uDNA) in vivo and in vitro. uDNA can be transcriptionally active, and circularized uDNA genomes are biochemically stable in non-proliferating cells. Resting, non-proliferati...

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發表在:Retrovirology
Main Authors: Chan, Chi N., Trinité, Benjamin, Lee, Caroline S., Mahajan, Saurabh, Anand, Akanksha, Wodarz, Dominik, Sabbaj, Steffanie, Bansal, Anju, Goepfert, Paul A., Levy, David N.
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700562/
https://ncbi.nlm.nih.gov/pubmed/26728316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0234-9
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