HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells

BACKGROUND: HIV-1 integration is prone to a high rate of failure, resulting in the accumulation of unintegrated viral genomes (uDNA) in vivo and in vitro. uDNA can be transcriptionally active, and circularized uDNA genomes are biochemically stable in non-proliferating cells. Resting, non-proliferati...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Chan, Chi N., Trinité, Benjamin, Lee, Caroline S., Mahajan, Saurabh, Anand, Akanksha, Wodarz, Dominik, Sabbaj, Steffanie, Bansal, Anju, Goepfert, Paul A., Levy, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700562/
https://ncbi.nlm.nih.gov/pubmed/26728316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0234-9
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