HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells

BACKGROUND: HIV-1 integration is prone to a high rate of failure, resulting in the accumulation of unintegrated viral genomes (uDNA) in vivo and in vitro. uDNA can be transcriptionally active, and circularized uDNA genomes are biochemically stable in non-proliferating cells. Resting, non-proliferati...

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Détails bibliographiques
Publié dans:Retrovirology
Auteurs principaux: Chan, Chi N., Trinité, Benjamin, Lee, Caroline S., Mahajan, Saurabh, Anand, Akanksha, Wodarz, Dominik, Sabbaj, Steffanie, Bansal, Anju, Goepfert, Paul A., Levy, David N.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700562/
https://ncbi.nlm.nih.gov/pubmed/26728316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0234-9
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