A First-Time-In-Human Phase I Clinical Trial of Bispecific Antibody-Targeted, Paclitaxel-Packaged Bacterial Minicells

BACKGROUND: We have harnessed a novel biological system, the bacterial minicell, to deliver cancer therapeutics to cancer cells. Preclinical studies showed that epidermal growth factor receptor (EGFR)-targeted, paclitaxel-loaded minicells ((EGFR)minicells(Pac)) have antitumor effects in xenograft mo...

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Detalles Bibliográficos
Publicado en:PLoS One
Autores principales: Solomon, Benjamin J., Desai, Jayesh, Rosenthal, Mark, McArthur, Grant A., Pattison, Scott T., Pattison, Stacey L., MacDiarmid, Jennifer, Brahmbhatt, Himanshu, Scott, Andrew M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699457/
https://ncbi.nlm.nih.gov/pubmed/26659127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144559
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