Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model

BACKGROUND: Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacter...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: MacDiarmid, Jennifer A., Langova, Veronika, Bailey, Dale, Pattison, Scott T., Pattison, Stacey L., Christensen, Neil, Armstrong, Luke R., Brahmbhatt, Vatsala N., Smolarczyk, Katarzyna, Harrison, Matthew T., Costa, Marylia, Mugridge, Nancy B., Sedliarou, Ilya, Grimes, Nicholas A., Kiss, Debra L., Stillman, Bruce, Hann, Christine L., Gallia, Gary L., Graham, Robert M., Brahmbhatt, Himanshu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822833/
https://ncbi.nlm.nih.gov/pubmed/27050167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151832
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