Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Stromal fibroblast senescence has been linked to aging-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAF) are frequently increased. Loss or down-modulation of the Notch effector CSL/RBP-Jκ in dermal fibroblasts is sufficient for CAF activation and ensui...

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Publicado en:Nat Cell Biol
Autores principales: Procopio, Maria-Giuseppina, Laszlo, Csaba, Labban, Dania Al, Kim, Dong Eun, Bordignon, Pino, Jo, Seunghee, Goruppi, Sandro, Menietti, Elena, Ostano, Paola, Ala, Ugo, Provero, Paolo, Hoetzenecker, Wolfram, Neel, Victor, Kilarski, Witek, Swartz, Melody A., Brisken, Cathrin, Lefort, Karine, Dotto, G. Paolo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699446/
https://ncbi.nlm.nih.gov/pubmed/26302407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3228
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