Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Stromal fibroblast senescence has been linked to aging-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAF) are frequently increased. Loss or down-modulation of the Notch effector CSL/RBP-Jκ in dermal fibroblasts is sufficient for CAF activation and ensui...

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Udgivet i:Nat Cell Biol
Main Authors: Procopio, Maria-Giuseppina, Laszlo, Csaba, Labban, Dania Al, Kim, Dong Eun, Bordignon, Pino, Jo, Seunghee, Goruppi, Sandro, Menietti, Elena, Ostano, Paola, Ala, Ugo, Provero, Paolo, Hoetzenecker, Wolfram, Neel, Victor, Kilarski, Witek, Swartz, Melody A., Brisken, Cathrin, Lefort, Karine, Dotto, G. Paolo
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699446/
https://ncbi.nlm.nih.gov/pubmed/26302407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3228
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