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Prostaglandin E(2) stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis

BACKGROUND: Cyclooxygenase-2-derived prostaglandin E(2) (PGE(2)), a bioactive eicosanoid, has been implicated in many biological processes including reproduction, inflammation and tumor growth. We previously showed that PGE(2) stimulated lung cancer cell growth and progression through PGE(2) recepto...

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Pubblicato in:Respir Res
Autori principali: Fan, Yu, Wang, Ye, Wang, Ke
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699375/
https://ncbi.nlm.nih.gov/pubmed/26684827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-015-0309-0
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