CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca(2+)-dependent apoptosis

The calcium and calmodulin-dependent kinase II (CaMKII) translates increases in intracellular Ca(2+) into downstream signaling events. Its function in pulmonary pathologies remains largely unknown. CaMKII is a well-known mediator of apoptosis and regulator of endoplasmic reticulum (ER) Ca(2+). ER st...

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Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Winters, Christopher J., Koval, Olha, Murthy, Shubha, Allamargot, Chantal, Sebag, Sara C., Paschke, John D., Jaffer, Omar A., Carter, A. Brent, Grumbach, Isabella M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698436/
https://ncbi.nlm.nih.gov/pubmed/26545899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00132.2015
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