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Cell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activity
Histone methylation is a prevalent and dynamic chromatin modification, executed by the action of histone methyltransferases (HMTs) and demethylases (HDMs). Aberrant activity of many of these enzymes is associated with human disease, hence, there is a growing interest in identifying corresponding sma...
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| Veröffentlicht in: | Drug Discov Today Technol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4698313/ https://ncbi.nlm.nih.gov/pubmed/26723887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2015.10.004 |
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