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Targeting insulin-degrading enzyme to treat type 2 diabetes
Insulin degrading enzyme (IDE) selectively degrades peptides such as insulin, amylin, and amyloid β (Aβ) that form toxic aggregates, to maintain proteostasis. IDE defects are linked to the development of type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). Structural and biochemical analyse...
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| Udgivet i: | Trends Endocrinol Metab |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4698235/ https://ncbi.nlm.nih.gov/pubmed/26651592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2015.11.003 |
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