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Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics
The ubiquitously expressed adapter proteins Nck1/2 interact with a multitude of effector molecules to regulate diverse cellular functions including cytoskeletal dynamics. Here we show that Nck1, but not Nck2, is a substrate of c-Cbl-mediated ubiquitination. We uncover lysine 178 in Nck1 as the evolu...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4698162/ https://ncbi.nlm.nih.gov/pubmed/24287595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3863 |
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