Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics

The ubiquitously expressed adapter proteins Nck1/2 interact with a multitude of effector molecules to regulate diverse cellular functions including cytoskeletal dynamics. Here we show that Nck1, but not Nck2, is a substrate of c-Cbl-mediated ubiquitination. We uncover lysine 178 in Nck1 as the evolu...

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Udgivet i:Nat Commun
Main Authors: Buvall, Lisa, Rashmi, Priyanka, Lopez-Rivera, Esther, Andreeva, Svetlana, Weins, Astrid, Wallentin, Hanna, Greka, Anna, Mundel, Peter
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698162/
https://ncbi.nlm.nih.gov/pubmed/24287595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3863
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