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Destruction of RhoA CULtivates actin
Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation thereby maintaining actin cytoskeleton integrity.
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3981991/ https://ncbi.nlm.nih.gov/pubmed/19782022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.012 |
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