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Destruction of RhoA CULtivates actin

Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation thereby maintaining actin cytoskeleton integrity.

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Detalles Bibliográficos
Main Authors: Wu, Shuangding, Wolf, Dieter A.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981991/
https://ncbi.nlm.nih.gov/pubmed/19782022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.012
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