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Iridium Catalyzed C-C Coupling of a Simple Propargyl Ether with Primary Alcohols: Enantioselective Homoaldol Addition via Redox-Triggered (Z)-Siloxyallylation
A chiral iridium complex formed in situ from [Ir(cod)Cl](2) and (R)-H(8)-BINAP is found to catalyze the direct enantioselective C-C coupling of a simple propargyl ether, TIPSOCH(2)C≡CH, with primary alcohols to form γ-hydroxy (Z)-enol silanes with uniformly high enantioselectivity and complete alken...
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| Publicado en: | J Am Chem Soc |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4697880/ https://ncbi.nlm.nih.gov/pubmed/26671223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b12131 |
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