Acyl-2-aminobenzimidazoles: a novel class of neuroprotective agents targeting mGluR5

Positive allosteric modulators (PAMs) of the metabotropic glutamate receptor 5 (mGluR5) are promising therapeutic agents for treating traumatic brain injury (TBI). Using computational and medicinal methods, the structure-activity relationship of a class of acyl-2-aminobenzimidazoles (1-26) is report...

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Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: He, Xinhua, Lakkaraju, Sirish K., Hanscom, Marie, Zhao, Zaorui, Wu, Junfang, Stoica, Bogdan, MacKerell, Alexander D., Faden, Alan I., Xue, Fengtian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697443/
https://ncbi.nlm.nih.gov/pubmed/25801156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.054
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