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Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5
Positive allosteric modulators (PAM) binding to the transmembrane (TM) domain of metabotropic glutamate receptor 5 (mGluR5) are promising therapeutic agents for psychiatric disorders and traumatic brain injury (TBI). Novel PAMs based on a trans-2-phenylcyclopropane amide scaffold have been designed...
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| Veröffentlicht in: | Bioorg Med Chem Lett |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4690453/ https://ncbi.nlm.nih.gov/pubmed/25937015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.04.042 |
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