Estimation of ligand efficacies of metabotropic glutamate receptors from conformational forces obtained from molecular dynamics simulations

Group 1 metabotropic glutamate receptors (mGluR) are G-protein coupled receptors with a large bilobate extracellular ligand binding region (LBR) that resembles a Venus fly trap. Closing of this LBR in the presence of a ligand is associated with the activation of the receptor. From conformational sam...

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Hauptverfasser: Lakkaraju, Sirish Kaushik, Xue, Fengtian, Faden, Alan I., MacKerell, Alexander D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693859/
https://ncbi.nlm.nih.gov/pubmed/23688150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci400160x
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