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Identification and Characterization of Fragment Binding Sites for Allosteric Ligand Design using the Site Identification by Ligand Competitive Saturation Hotspots Approach (SILCS-Hotspots)
BACKGROUND: Fragment-based ligand design is used for the development of novel ligands that target macromolecules, most notably proteins. Central to its success is the identification of fragment binding sites that are spatially adjacent such that fragments occupying those sites may be linked to creat...
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| Published in: | Biochim Biophys Acta Gen Subj |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7029399/ https://ncbi.nlm.nih.gov/pubmed/31911242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2020.129519 |
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