Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine

Acute amphetamine (AMPH) exposure elevates extracellular dopamine through a variety of mechanisms that include inhibition of dopamine reuptake, depletion of vesicular stores, and facilitation of dopamine efflux across the plasma membrane. Recent work has shown that the DAT substrate AMPH, unlike coc...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wheeler, David S., Underhill, Suzanne M., Stolz, Donna B., Murdoch, Geoffrey H., Thiels, Edda, Romero, Guillermo, Amara, Susan G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697400/
https://ncbi.nlm.nih.gov/pubmed/26553986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511670112
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