Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine

Acute amphetamine (AMPH) exposure elevates extracellular dopamine through a variety of mechanisms that include inhibition of dopamine reuptake, depletion of vesicular stores, and facilitation of dopamine efflux across the plasma membrane. Recent work has shown that the DAT substrate AMPH, unlike coc...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wheeler, David S., Underhill, Suzanne M., Stolz, Donna B., Murdoch, Geoffrey H., Thiels, Edda, Romero, Guillermo, Amara, Susan G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697400/
https://ncbi.nlm.nih.gov/pubmed/26553986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511670112
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