Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

Cerebral organoids—3D cultures of human cerebral tissue derived from pluripotent stem cells—have emerged as models of human cortical development. However, the extent to which in vitro organoid systems recapitulate neural progenitor cell proliferation and neuronal differentiation programs observed in...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Camp, J. Gray, Badsha, Farhath, Florio, Marta, Kanton, Sabina, Gerber, Tobias, Wilsch-Bräuninger, Michaela, Lewitus, Eric, Sykes, Alex, Hevers, Wulf, Lancaster, Madeline, Knoblich, Juergen A., Lachmann, Robert, Pääbo, Svante, Huttner, Wieland B., Treutlein, Barbara
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697386/
https://ncbi.nlm.nih.gov/pubmed/26644564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520760112
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