Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

Cerebral organoids—3D cultures of human cerebral tissue derived from pluripotent stem cells—have emerged as models of human cortical development. However, the extent to which in vitro organoid systems recapitulate neural progenitor cell proliferation and neuronal differentiation programs observed in...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Camp, J. Gray, Badsha, Farhath, Florio, Marta, Kanton, Sabina, Gerber, Tobias, Wilsch-Bräuninger, Michaela, Lewitus, Eric, Sykes, Alex, Hevers, Wulf, Lancaster, Madeline, Knoblich, Juergen A., Lachmann, Robert, Pääbo, Svante, Huttner, Wieland B., Treutlein, Barbara
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697386/
https://ncbi.nlm.nih.gov/pubmed/26644564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520760112
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