Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes

Exogenous cytokine therapy can induce systemic toxicity, which might be prevented by activating endogenously produced cytokines in local cell niches. Here we developed antibody-based activators of cytokine signaling (AcCS), which recognize cytokines only when they are bound to their cell surface rec...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Kuruganti, Srilalitha, Miersch, Shane, Deshpande, Ashlesha, Speir, Jeffrey A., Harris, Bethany D., Schriewer, Jill M., Buller, R. Mark L., Sidhu, Sachdev S., Walter, Mark R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697184/
https://ncbi.nlm.nih.gov/pubmed/26546677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665943
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