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Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines

Interleukin 20 (IL-20) is a pleotropic IL-10 family cytokine that protects epithelial surfaces from pathogens. However, dysregulated IL-20 signaling is implicated in several human pathologies including psoriasis, rheumatoid arthritis, atherosclerosis, and osteoporosis. IL-20, and related cytokines I...

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Bibliografiske detaljer
Main Authors: Logsdon, Naomi J., Deshpande, Ashlesha, Harris, Bethany D., Rajashankar, Kanagalaghatta R., Walter, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412030/
https://ncbi.nlm.nih.gov/pubmed/22802649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117551109
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