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Structural basis of receptor sharing by interleukin 17 cytokines

T helper type 17 (T(H)-17) cells, together with their effector cytokines including interleukin 17 (IL-17) family members, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Here we present the crystal structure of a 1:2 complex of IL-17RA bound to IL-17F. The manner of c...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ely, Lauren K., Fischer, Suzanne, Garcia, K. Christopher
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783927/
https://ncbi.nlm.nih.gov/pubmed/19838198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1813
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