Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain

IL-10R2 is a shared cell surface receptor required for the activation of five class 2 cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) that play critical roles in host defense. To define the molecular mechanisms that regulate its promiscuous binding, we have determined the crystal structure of the...

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Autori principali: Yoon, Sung-il, Jones, Brandi C., Logsdon, Naomi J., Harris, Bethany D., Deshpande, Ashlesha, Radaeva, Svetlana, Halloran, Brian A., Gao, Bin, Walter, Mark R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879597/
https://ncbi.nlm.nih.gov/pubmed/20462497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.02.009
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