Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling

TGF-β is a pleiotropic cytokine that regulates a wide range of cellular actions and pathophysiological processes. TGF-β signaling is spatiotemporally fine-tuned. As a key negative regulator of TGF-β signaling, Smad7 exerts its inhibitory effects by blocking receptor activity, inducing receptor degra...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Yan, Xiaohua, Liao, Hongwei, Cheng, Minzhang, Shi, Xiaojing, Lin, Xia, Feng, Xin-Hua, Chen, Ye-Guang
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697173/
https://ncbi.nlm.nih.gov/pubmed/26555259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.694281
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