Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition

MTORC2-AKT is a key regulator of carbohydrate metabolism and insulin signaling due to its effects on FOXO1 phosphorylation. Interestingly, both FOXO1 and thyroid hormone (TH) have similar effects on carbohydrate and energy metabolism as well as overlapping transcriptional regulation of many target g...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Singh, Brijesh K., Sinha, Rohit A., Zhou, Jin, Tripathi, Madhulika, Ohba, Kenji, Wang, Mu-En, Astapova, Inna, Ghosh, Sujoy, Hollenberg, Anthony N., Gauthier, Karine, Yen, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697156/
https://ncbi.nlm.nih.gov/pubmed/26453307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668673
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